Thionyl Chloride → 2-Chloro-4-(chloromethyl)-6-methylpyridine

HRID 2099825Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2099825
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8]O)[CH:5]=[C:4]([CH3:10])[N:3]=1.S(Cl)([Cl:13])=O>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][Cl:13])[CH:5]=[C:4]([CH3:10])[N:3]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 22504306(2-Chloro-6-methylpyridin-4-yl)methanol

Produkt 1

HCID 216981672-Chloro-4-(chloromethyl)-6-methylpyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

(2-Chloro-6-methylpyridin-4-yl)methanol (0.212 g, 1.35 mmol) and thionyl chloride (0.12 mL, 1.62 mmol) were combined in methylene chloride (4 mL) and stirred at room temperature for 4 h. The solvents were removed and the product dried under vacuum for several hours to afford 0.24 g (quant.) as a clear oil which was used without purification. Mass spec.: 176.0 (MH)+.

Aufarbeitung

  1. customThe solvents were removed
  2. customthe product dried under vacuum for several hours
  3. customto afford 0.24 g (quant.) as a clear oil which
  4. customwas used without purification

Quellen und Nachweise

ORD-Eintrag
ord-2f6899c5c0574523b8288fa8836090b8
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07569578B2

Notizen zur Reaktion

Wird geladen…