4-chloro-3-nitro-N-(pyridin-3-ylmethyl)benzenesulfonamide → 4-Amino-3-nitro-N-(3-pyridinylmethyl)benzenesulfonamide

HRID 2099848Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2099848
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:19]([O-:21])=[O:20].[NH3:22].CO>>[NH2:22][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:19]([O-:21])=[O:20]

Komponenten

3

Edukt 2

HCID 28583054-chloro-3-nitro-N-(pyridin-3-ylmethyl)benzenesulfonamideHCID 21705897Ammonia methanol

Produkt 1

HCID 222851684-Amino-3-nitro-N-(3-pyridinylmethyl)benzenesulfonamide

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Into a saturated ammonia-methanol solution (60 ml) was added 4-chloro-3-nitro-N-(pyridin-3-ylmethyl)benzenesulfonamide (2.77 g), followed by about 2 days of heating at 100° C. in a sealed tube. After the reaction, the solvent was evaporated under reduced pressure and the formed yellow crystals were collected by filtration and dried to obtain 4-amino-3-nitro-N-(pyridin-3-ylmethyl)benzenesulfonamide (2.51 g). Hereinafter, the compound of Reference Examples 26 was obtained similarly.

Aufarbeitung

  1. customAfter the reaction
  2. customthe solvent was evaporated under reduced pressure
  3. filtrationthe formed yellow crystals were collected by filtration
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-80a05f61f7974e20b26e77a75147fa75
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07569688B2

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