4-Acetylmorpholine → 2-(4-morpholinyl)-8-phenoxy-4H-1-benzopyran-4-one

Beteiligte Stoffe

Reaktionsschritte

Condensation of the lithium enolate of N-acetyl morpholine (0.21 g, 1.6 mmol) with methyl 3-phenoxy-2-hydroxybenzoate (0.25 g, 1.0 mmol) followed by cyclodehydration with trifluoromethanesulfonic anhydride (0.60 ml, 3.6 mmol) as described above yielded TGX-134 as an off-white solid (0.090 g).

Herkunft & Nachweise