Morpholine-4-carboxamide → 2-({2-[(Morpholine-4-carbonyl)-amino]-pyridin-4-ylmethyl}-amino)-benzoic acid methyl ester

HRID 2100431

Reaktionsgleichung

Reaktionsgleichung von HRID 2100431
[CH3:1][O:2][C:3](=[O:19])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][CH2:11][C:12]1[CH:17]=[CH:16][N:15]=[C:14](Br)[CH:13]=1.[N:20]1([C:26]([NH2:28])=[O:27])[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>>[CH3:1][O:2][C:3](=[O:19])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][CH2:11][C:12]1[CH:17]=[CH:16][N:15]=[C:14]([NH:28][C:26]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)=[O:27])[CH:13]=1

Komponenten

3

Edukt 2

HCID 75088Morpholine-4-carboxamideHCID 58763671Methyl 2-{[(2-bromopyridin-4-yl)methyl]amino}benzoate

Produkt 1

HCID 577989192-({2-[(Morpholine-4-carbonyl)-amino]-pyridin-4-ylmethyl}-amino)-benzoic acid methyl ester

Versuchsvorschrift

2-({2-[(Morpholine-4-carbonyl)-amino]-pyridin-4-ylmethyl}-amino)-benzoic acid methyl ester was prepared from 2-[(2-bromo-pyridin-4-ylmethyl)-amino]-benzoic acid methyl ester and morpholine-4-carboxylic acid amide in analogy to the procedures detailed in WO2004/013102, particularly Example 6A, supra; 1H-NMR (300 MHz, d6-DMSO) 9.19 (1H, s), 8.15-8.19 (2H, m), 7.79-7.84 (2H, m), 7.29-7.34 (1H, m), 6.92 (1H, dd), 6.56-6.62 (2H, m), 4.50 (2H, d), 3.83 (3H, s), 3.57-3.60 (4H, m), 3.42-3.46 (4H, m).

Quellen und Nachweise

ORD-Eintrag
ord-e97c3ada0e4745bfb7593e2594e51614
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07572794B2

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