4-Methyl-3-thiopheneboronic acid → (5-methyl-1H-pyrazol-3-yl)-[1-(4-methyl-thiophen-3-yl)-isoquinolin-3-yl]-amine

HRID 2100904

Reaktionsgleichung

Reaktionsgleichung von HRID 2100904
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[C:16]([CH3:18])[NH:15][N:14]=2)[N:3]=1.[CH3:19][C:20]1[C:21](B(O)O)=[CH:22][S:23][CH:24]=1>>[CH3:18][C:16]1[NH:15][N:14]=[C:13]([NH:12][C:4]2[N:3]=[C:2]([C:21]3[C:20]([CH3:19])=[CH:24][S:23][CH:22]=3)[C:11]3[C:6]([CH:5]=2)=[CH:7][CH:8]=[CH:9][CH:10]=3)[CH:17]=1

Komponenten

3

Edukt 2

HCID 50839314-Methyl-3-thiopheneboronic acidHCID 57799635(1-chloro-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

Produkt 1

HCID 57799739(5-methyl-1H-pyrazol-3-yl)-[1-(4-methyl-thiophen-3-yl)-isoquinolin-3-yl]-amine

Versuchsvorschrift

Similar procedure as described in example 131 was used, starting from (1-chloro-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and 4-methyl-thiophene-3-boronic acid to give (5-methyl-1H-pyrazol-3-yl)-[1-(4-methyl-thiophen-3-yl)-isoquinolin-3-yl]-amine. LC-MS m/e 321(MH+).

Quellen und Nachweise

ORD-Eintrag
ord-27a1c5403bb446c7856beceeff8f3cb3
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07572809B2

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