4,4,5,5-Tetramethyl-2-(prop-1-en-2-yl)-1,3,2-dioxaborolane → HCID 23633713, Verbindung
Reaktionsgleichung
Cl[C:2]1[C:11]2[C:6](=[C:7]([O:12][CH3:13])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=2)[N:3]=1.[C:21](B1OC(C)(C)C(C)(C)O1)([CH3:23])=[CH2:22]>>[CH:21]([C:2]1[C:11]2[C:6](=[C:7]([O:12][CH3:13])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=2)[N:3]=1)([CH3:23])[CH3:22]Komponenten
3
Versuchsvorschrift
Similar procedure as described in example 330 was used, starting from (1-Chloro-5-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and isopropenylboronic acid pinacol ester to give (1-Isopropyl-5-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS m/e 297(MH+).
Quellen und Nachweise
- ORD-Eintrag
- ord-73946bb22b824717801daba7a1dd24db
- Quelldatensatz
- uspto-grants-2009_08
- Patentnummer
- US07572809B2
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