(1,5-Dichloro-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine → (5-Chloro-1-isopropoxy-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine
Reaktionsgleichung
Cl[C:2]1[C:11]2[C:6](=[C:7]([Cl:16])[C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[CH:5]=[C:4]([NH:17][C:18]2[CH:22]=[C:21]([CH3:23])[NH:20][N:19]=2)[N:3]=1>C(O)(C)C>[Cl:16][C:7]1[C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=[C:11]2[C:6]=1[CH:5]=[C:4]([NH:17][C:18]1[CH:22]=[C:21]([CH3:23])[NH:20][N:19]=1)[N:3]=[C:2]2[O:12][CH:9]([CH3:10])[CH3:8]Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Similar procedure as described in example 376 was used, starting from (1,5-Dichloro-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and isopropanol to give (5-Chloro-1-isopropoxy-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS: m/e 377 (MH+).