Hydrochloric Acid → 6-(3-Methylbenzofuran-2-sulfonyl)-2h-pyridazin-3-one

HRID 2101440Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2101440
C[O:2][C:3]1[N:4]=[N:5][C:6]([S:9]([C:12]2[O:13][C:14]3[CH:21]=[CH:20][C:19](Cl)=[CH:18][C:15]=3[C:16]=2[CH3:17])(=[O:11])=[O:10])=[CH:7][CH:8]=1.Cl>O1CCOCC1>[CH3:17][C:16]1[C:15]2[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=2[O:13][C:12]=1[S:9]([C:6]1[CH:7]=[CH:8][C:3](=[O:2])[NH:4][N:5]=1)(=[O:11])=[O:10]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 99458133-Methoxy-6-(5-chloro-3-methyl-benzofuran-2-sulfonyl)-pyridazine

Produkt 1

HCID 115075536-(3-Methylbenzofuran-2-sulfonyl)-2h-pyridazin-3-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 3-methoxy-6-(5-chloro-3-methyl-benzofuran-2-sulfonyl)-pyridazine (0.5 mmol, 162 mg), conc. HCl (1 mL), and dioxane (3 mL) was heated at 100° C. for 2 hours. The reaction mixture was cooled and evaporated to dryness. Water (10 mL) was added to the residue. The resulting yellow precipitate was collected and crystallized from ethanol to obtain the desired product: 6-(3-methyl-benzofuran-2-sulfonyl)-2H-pyridazin-3-one (73%, 113 mg); mp 247° C.-248° C.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. customevaporated to dryness
  3. additionWater (10 mL) was added to the residue
  4. customThe resulting yellow precipitate was collected
  5. customcrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-f6efa981e1f343878a1be3100e483fca
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07572910B2

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