Methanol → HCID 67337219, Verbindung

HRID 2102239Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2102239
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)[N:11](CC3C=CC(C(OC)=O)=CC=3)[N:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH3:33][OH:34].[OH-:35].[Na+]>C1COCC1>[Cl:8][C:6]1[CH:5]=[C:4]([C:9]2[N:10]([CH2:9][C:4]3[CH:5]=[CH:6][C:7]([C:33]([OH:35])=[O:34])=[CH:2][CH:3]=3)[N:11]=[C:12]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)[CH:13]=2)[CH:3]=[C:2]([Cl:1])[CH:7]=1

Komponenten

5

Edukt 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 68983278HCID 68983278, Verbindung

Produkt 1

HCID 67337219HCID 67337219, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of the intermediate from example 73 step C (Isomer B, 0.43 g, 0.92 mmol) in THF (30 mL) was added methanol (10 mL) followed by sodium hydroxide solution (2N, 2 mL, 4 mmol). The reaction was stirred at room temperature overnight. The reaction mixture was concentrated in vacuo to remove the organic solvents. The residue was acidified with 1N HCl until the pH was less than 2. The resulting solution was extracted with ethyl acetate (3×) dried over anhydrous Na2SO4, filtered and concentrated in vacuo to give the title compound as a white solid. This material was used in the next step without any further purification. 1H NMR (DMSO, 500 MHz): δ 7.86(d, J=8.5 Hz, 2H), 7.77(d, J=8.7 Hz, 2H), 7.67(s, 1H), 7.5(d, J=1.8 Hz, 2H), 7.14(d, J=8.3 Hz, 2H), 7.04(s, 1H), 6.98(d, J=8.9 Hz, 2H), 5.52(s, 2H), 3.77(s, 3H). LC-MS: 2.55 min; (M+H)=453.1.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customto remove the organic solvents
  3. extractionThe resulting solution was extracted with ethyl acetate (3×)
  4. dry with materialdried over anhydrous Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f35c113fda3f4b8eb2d786d1c7d85999
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07572922B2

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