N-bromobutanimide → HCID 178470082, Verbindung

HRID 2102258Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2102258
[OH:1][C:2]1[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][N:4]([CH:12]([CH3:14])[CH3:13])[N:3]=1.[Br:15]N1C(=O)CCC1=O>ClCCl>[Br:15][C:5]1[N:4]([CH:12]([CH3:13])[CH3:14])[N:3]=[C:2]([OH:1])[C:6]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8]

Komponenten

4

Edukt 2

HCID 67184N-bromobutanimideHCID 178469772Ethyl 3-hydroxy-1-isopropylpyrazole-4-carboxylate

Produkt 1

HCID 178470082HCID 178470082, VerbindungAusbeute 40,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Ethyl 3-hydroxy-1-isopropylpyrazole-4-carboxylate (10.5 g) was dissolved in dichloromethane (100 mL) and to the stirred solution was added N-bromosuccinimide (14.1 g) under ice cooling. The reaction mixture was stirred at room temperature for 6 hours. The solvent was removed under reduced pressure and the obtained residue was purified by column chromatography on silica gel (eluent: ethyl acetate/hexane=1/5) to give 5.9 g of the title compound.

Aufarbeitung

  1. customThe solvent was removed under reduced pressure
  2. customthe obtained residue was purified by column chromatography on silica gel (eluent: ethyl acetate/hexane=1/5)

Quellen und Nachweise

ORD-Eintrag
ord-1f83431b0f7d4bb0a2940084453d2648
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07576064B2

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