Sodium Chloride → N,N-Dimethyl-N'-(5-bromothiophene-2-sulfonyl)formamidine

HRID 2103615Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2103615
CO[CH:3]([N:6]([CH3:8])[CH3:7])OC.[Br:9][C:10]1[S:14][C:13]([S:15]([NH2:18])(=[O:17])=[O:16])=[CH:12][CH:11]=1.[Cl-].[Na+]>CN(C=O)C>[CH3:7][N:6]([CH:3]=[N:18][S:15]([C:13]1[S:14][C:10]([Br:9])=[CH:11][CH:12]=1)(=[O:17])=[O:16])[CH3:8]

Komponenten

5

Edukt 3

HCID 5234Sodium ChlorideHCID 78373Dimethylformamide dimethyl acetalHCID 12413045-Bromo-2-thiophenesulfonamide

Produkt 1

HCID 54319951N,N-Dimethyl-N'-(5-bromothiophene-2-sulfonyl)formamidineAusbeute 114,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Add dimethoxymethyl-dimethyl-amine (1.05 mL, 7.66 mmol) to a solution-of 5-bromo-thiophene-2-sulfonic acid amide (1.8 g, 7.43 mmol) in DMF (3 mL) at r.t. for 16 h. Pour reaction mixture into saturated sodium chloride, extract with ethylacetate. Wash combined organic layers with water, dry over sodium sulfate and remove solvent to obtain 2.52 g product. MS (m/e): 297.0/299.0 (M+H).

Aufarbeitung

  1. additionPour
  2. extractionextract with ethylacetate
  3. washWash
  4. dry with materialdry over sodium sulfate
  5. customremove solvent

Quellen und Nachweise

ORD-Eintrag
ord-c03efdef1d594c498a5dc8be1f6972cb
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07576108B2

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