HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Pyridinemethanamine → 4-Chloro-7-{1-(tert-butoxycarbonyl)-5-[(pyridin-4-ylmethyl)amino methyl]indol-2-yl}isoindolinone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Pyridinemethanamine | HCID 77317 | — |
| Edukt | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Edukt | 4-Chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone | HCID 86628227 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 4-Chloro-7-{1-(tert-butoxycarbonyl)-5-[(pyridin-4-ylmethyl)amino methyl]indol-2-yl}isoindolinone | HCID 68490833 | — |
Reaktionsschritte
In a similar manner to Step 1 of Example 56, 4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone (20.0 mg, 0.0487 mmol) was dissolved in dichloromethane (0.5 mL). The solution was treated with 4-(aminomethyl)pyridine (0.010 mL, 0.099 mmol) and sodium triacetoxyborohydride (32 mg, 0.15 mmol) to obtain 4-chloro-7-{1-(tert-butoxycarbonyl)-5-[(pyridin-4-ylmethyl)amino methyl]indol-2-yl}isoindolinone.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07745641B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-4535dd18971347c396c6531b85d12b93 |
| Quellennotiz | uspto-grants-2010_06 |