HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Cyclohexanemethylamine → 4-Chloro-7-[1-(tert-butoxycarbonyl)-5-(cyclohexylmethylaminomethyl)indol-2-yl]isoindolinone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Cyclohexanemethylamine | HCID 76688 | — |
| Edukt | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Edukt | 4-Chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone | HCID 86628227 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 4-Chloro-7-[1-(tert-butoxycarbonyl)-5-(cyclohexylmethylaminomethyl)indol-2-yl]isoindolinone | HCID 68491943 | — |
Reaktionsschritte
In a similar manner to Step 1 of Example 56, 4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone (20.0 mg, 0.0487 mmol) was dissolved in dichloromethane (0.5 mL). The solution was treated with cyclohexanemethylamine (0.026 mL, 0.20 mmol) and sodium triacetoxyborohydride (32 mg, 0.15 mmol) to obtain 4-chloro-7-[1-(tert-butoxycarbonyl)-5-(cyclohexylmethylaminomethyl)indol-2-yl]isoindolinone.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07745641B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-e2d52e0f07e14f71a404eeb6d4605acc |
| Quellennotiz | uspto-grants-2010_06 |