Triethylsilane → 2-Chloro-4-ethyl-1-fluorobenzene
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=O)[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].C([SiH](CC)CC)C>C(O)(C(F)(F)F)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH3:10])[CH:5]=[CH:6][C:7]=1[F:8]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 3′-chloro-4′-fluoroacetophenone (5.2 g, 30.1 mmol) in 30 mL TFA, was added triethylsilane (14.4 mL, 90.4 mmol). The mixture was stirred at rt for 15 h, then concentrated. The crude product was purified by flash chromatography (100% hexanes, 2×) to afford 1.35 g of Intermediate 221.1 as a colorless oil.
Aufarbeitung
- concentrationconcentrated
- customThe crude product was purified by flash chromatography (100% hexanes, 2×)
Quellen und Nachweise
- ORD-Eintrag
- ord-e628bb131f7d41c080af62910a34c143
- Quelldatensatz
- uspto-grants-2009_08
- Patentnummer
- US07576098B2
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