Triethylsilane → 2-Chloro-4-ethyl-1-fluorobenzene

HRID 2105028

Reaktionsgleichung

Reaktionsgleichung von HRID 2105028
[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=O)[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].C([SiH](CC)CC)C>C(O)(C(F)(F)F)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH3:10])[CH:5]=[CH:6][C:7]=1[F:8]

Komponenten

4

Edukt 2

HCID 12052TriethylsilaneHCID 5204223'-Chloro-4'-fluoroacetophenone

Produkt 1

HCID 187118782-Chloro-4-ethyl-1-fluorobenzeneAusbeute 28,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

To a solution of 3′-chloro-4′-fluoroacetophenone (5.2 g, 30.1 mmol) in 30 mL TFA, was added triethylsilane (14.4 mL, 90.4 mmol). The mixture was stirred at rt for 15 h, then concentrated. The crude product was purified by flash chromatography (100% hexanes, 2×) to afford 1.35 g of Intermediate 221.1 as a colorless oil.

Aufarbeitung

  1. concentrationconcentrated
  2. customThe crude product was purified by flash chromatography (100% hexanes, 2×)

Quellen und Nachweise

ORD-Eintrag
ord-e628bb131f7d41c080af62910a34c143
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07576098B2

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