2-Butanamine, (S)- → HCID 58999037, Verbindung

Reaktionsgleichung

CO[C:3]([C:5]1[C:9]([CH3:10])=[C:8]([C:11]2[CH:16]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:14]=[C:13]([C:21]([F:24])([F:23])[F:22])[CH:12]=2)[N:7]([CH2:25][CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)[C:6]=1[CH3:32])=[O:4].[C@@H:33]([NH2:37])([CH2:35][CH3:36])[CH3:34]>>[C@@H:33]([NH:37][C:3]([C:5]1[C:9]([CH3:10])=[C:8]([C:11]2[CH:12]=[C:13]([C:21]([F:22])([F:23])[F:24])[CH:14]=[C:15]([C:17]([F:20])([F:18])[F:19])[CH:16]=2)[N:7]([CH2:25][CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)[C:6]=1[CH3:32])=[O:4])([CH2:35][CH3:36])[CH3:34]

Komponenten

Edukt 2

HCID 67137532-Butanamine, (S)-

HCID 86594074HCID 86594074, Verbindung

Produkt 1

HCID 58999037HCID 58999037, Verbindung

Versuchsvorschrift

The title compound was synthesized in analogy to example 203, from 5-(3,5-bis-trifluoromethyl-phenyl)-1-cyclohexylmethyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid methyl ester and (S)-sec-butylamine as R1R2NH, MS (ISP) 503.4 (M+H)+.

Quellen und Nachweise

ORD-Eintrag: ord-742cd1d786184b88a2cf47cba1258da7
Quelldatensatz: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07579369B2

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