[O:1]1[CH2:6][CH2:5][CH2:4][O:3][CH:2]1[C:7]1[CH:8]=[C:9]([C:13]([CH3:22])([CH3:21])[CH2:14][C:15](=[O:20])[C:16]([F:19])([F:18])[F:17])[CH:10]=[CH:11][CH:12]=1.[Na].[I-].[CH3:25][S+](C)(C)=O>CS(C)=O>[CH3:21][C:13]([C:9]1[CH:8]=[C:7]([CH:2]2[O:3][CH2:4][CH2:5][CH2:6][O:1]2)[CH:12]=[CH:11][CH:10]=1)([CH3:22])[CH2:14][C:15]1([C:16]([F:18])([F:19])[F:17])[CH2:25][O:20]1To a solution of 4-(3-[1,3]dioxan-2-ylphenyl)-1,1,1-trifluoro-4-methylpentan-2-one (1 g, 3 mmol) in 4.1 mL of anhydrous DMSO was added the sodium ylide of trimethylsulfoxonium iodide (3.0 mL of a 0.8M solution in DMSO) over 5 minutes. The reaction was stirred 2 hours and quenched with water and ethyl acetate. The organic layer was washed with water and brine, and dried over sodium sulfate. Removal of the volatiles in vacuo afforded 2-{3-[1,1-dimethyl-2-(2-trifluoromethyloxiranyl)ethyl]phenyl}-[1,3]dioxane as a yellow oil.
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