Sodium hydride → Ethyl 2-{[1-(4-chlorophenyl)-1H-1,2,4-triazol-3-yl]oxy}propanoate

HRID 2106579Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2106579
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[N:11][C:10]([OH:13])=[N:9]2)=[CH:4][CH:3]=1.[H-].[Na+].Br[CH:17]([CH3:23])[C:18]([O:20][CH2:21][CH3:22])=[O:19]>CS(C)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[N:11][C:10]([O:13][CH:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH3:23])=[N:9]2)=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 24758Sodium hydrideHCID 79040Ethyl 2-bromopropionateHCID 178518003HCID 178518003, Verbindung

Produkt 1

HCID 163820Ethyl 2-{[1-(4-chlorophenyl)-1H-1,2,4-triazol-3-yl]oxy}propanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

Six g of 1-(4-chlorophenyl)-3-hydroxy-1,2,4-1H-triazole was added to a suspension of 1.5 g of sodium hydride in 225 ml of dimethylsulfoxide. The mixture was heated on the steam bath for 90 minutes. Then 5.5 g of ethyl 2-bromopropionate was added and the mixture was heated for 90 minutes more. It was then cooled and poured over ice-water, and the solid was collected, dried and recrystallized from toluene to obtain 1.5 g of the desired product, m.p. 62°-64°.

Aufarbeitung

  1. temperatureThe mixture was heated on the steam bath for 90 minutes
  2. temperaturethe mixture was heated for 90 minutes more
  3. temperatureIt was then cooled
  4. customthe solid was collected
  5. customdried
  6. customrecrystallized from toluene

Quellen und Nachweise

ORD-Eintrag
ord-3c81752852e9487eb4db2b13c5311517
Quelldatensatz
uspto-grants-1990_06
Patentnummer
US04931083

Notizen zur Reaktion

Wird geladen…