Methanol → Propanoic acid, 2-((1-(3-chlorophenyl)-5-methyl-1H-1,2,4-triazol-3-yl)oxy)-, ethyl ester

HRID 2106580Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2106580
[Na].CO.[Cl:4][C:5]1[CH:6]=[C:7]([N:11]2[C:15]([CH3:16])=[N:14][C:13]([OH:17])=[N:12]2)[CH:8]=[CH:9][CH:10]=1.Br[CH:19]([CH3:25])[C:20]([O:22][CH2:23][CH3:24])=[O:21]>CS(C)=O>[Cl:4][C:5]1[CH:6]=[C:7]([N:11]2[C:15]([CH3:16])=[N:14][C:13]([O:17][CH:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH3:25])=[N:12]2)[CH:8]=[CH:9][CH:10]=1

Komponenten

6

Edukt 4

HCID 887MethanolHCID 79040Ethyl 2-bromopropionateHCID 5360545SodiumHCID 178433515HCID 178433515, Verbindung

Produkt 1

HCID 163821Propanoic acid, 2-((1-(3-chlorophenyl)-5-methyl-1H-1,2,4-triazol-3-yl)oxy)-, ethyl esterAusbeute 68 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

The process was carried out as was Example 9 above, starting with 0.8 g of sodium, 20 ml of methanol, 75 ml of dimethylsulfoxide, 7.8 g of 1-(3-chlorophenyl)-3-hydroxy-5-methyl-1,2,4-1H-triazole and 6.7 g of ethyl 2-bromopropionate. The yield was 7.8 g of the desired product, an oil.

Quellen und Nachweise

ORD-Eintrag
ord-7bdb0280f5674c1ca46931c397fad17e
Quelldatensatz
uspto-grants-1990_06
Patentnummer
US04931083

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