Triphenylphosphine → (tert-Butoxycarbonylmethyl)triphenylphosphonium Bromide

HRID 2106870Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2106870
[C:1]1([P:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:20][CH2:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23]>C1C=CC=CC=1>[Br-:20].[C:22]([CH2:21][P+:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23]

Komponenten

4

Edukt 2

HCID 11776TriphenylphosphineHCID 79177tert-Butyl bromoacetate

Produkt 1

HCID 2733853(tert-Butoxycarbonylmethyl)triphenylphosphonium BromideAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

A solution of triphenylphosphine (33.8 g, 129 mmol) and t-butyl bromoacetate (25 g, 128.2 mmol) in dry benzene (150 ml) was stirred for 16 hours at room temperature. The precipitated product was collected by filtration, washed with dry ether and dried in vacuo to give 56 g (96% of theory) of carbo-t-butoxymethyl triphenylphosphonium bromide.

Aufarbeitung

  1. filtrationThe precipitated product was collected by filtration
  2. washwashed with dry ether
  3. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f6b3f10780de4177b168c8ba64a75c9b
Quelldatensatz
uspto-grants-1990_06
Patentnummer
US04931469

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