Ammonia → 5-{1-Ethoxycarbonyl-1-[2-[3-(2,6-xylyl)ureido]thiazol-4-yl]-methylene}rhodanine-3-acetic acid

HRID 2107187Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2107187
[C:1]1([NH:9][C:10](=[O:24])[NH:11][C:12]2[S:13][CH:14]=[C:15]([C:17](=O)[C:18]([O:20][CH2:21][CH3:22])=[O:19])[N:16]=2)[C:6]([CH3:7])=[CH:5][CH:4]=[CH:3][C:2]=1[CH3:8].[S:25]1[CH2:31][C:29](=[O:30])[N:28]([CH2:32][C:33]([OH:35])=[O:34])[C:26]1=[S:27].[Cl-].[NH4+].N>C(O)C>[CH2:21]([O:20][C:18]([C:17](=[C:31]1[S:25][C:26](=[S:27])[N:28]([CH2:32][C:33]([OH:35])=[O:34])[C:29]1=[O:30])[C:15]1[N:16]=[C:12]([NH:11][C:10]([NH:9][C:1]2[C:6]([CH3:7])=[CH:5][CH:4]=[CH:3][C:2]=2[CH3:8])=[O:24])[S:13][CH:14]=1)=[O:19])[CH3:22]

Komponenten

6

Edukt 4

HCID 222AmmoniaHCID 25517Ammonium ChlorideHCID 797933-Thiazolidineacetic acid, 4-oxo-2-thioxo-HCID 15053505HCID 15053505, Verbindung

Produkt 1

HCID 540360675-{1-Ethoxycarbonyl-1-[2-[3-(2,6-xylyl)ureido]thiazol-4-yl]-methylene}rhodanine-3-acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Following a procedure similar to that described in Example 1, the desired compound was prepared using 1.74 g of ethyl 2-[3-(2,6-xylyl)ureido]thiazol-4-ylglyoxylate, 0.96 g of rhodanine-3-acetic acid, O.5 g of ammonium chloride. 0.5 ml of 28% v/v aqueous ammonia and 20 ml of ethanol. The resulting product was a yellow powder having the following physical properties.

Quellen und Nachweise

ORD-Eintrag
ord-5af90e7864af42a89aeaefcae6790ccd
Quelldatensatz
uspto-grants-1990_06
Patentnummer
US04933355

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