Ethyl 2-(cyclohexylamino)-1,3-thiazole-4-carboxylate → 2-Cyclohexylaminothiazol-4-ylmethanol
Reaktionsgleichung
[CH:1]1([NH:7][C:8]2[S:9][CH:10]=[C:11]([C:13](OCC)=[O:14])[N:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH:1]1([NH:7][C:8]2[S:9][CH:10]=[C:11]([CH2:13][OH:14])[N:12]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
The reaction described in Preparation 15 was repeated, but using 19 g of ethyl 2-cyclohexylaminothiazole-4-carboxylate, 4.2 g of lithium aluminum hydride and 250 ml of tetrahydrofuran, giving the title compound as pale yellow needles.
Aufarbeitung
- customThe reaction described in Preparation 15
Quellen und Nachweise
- ORD-Eintrag
- ord-89bae77397e94dfe9821863506d66151
- Quelldatensatz
- uspto-grants-1990_06
- Patentnummer
- US04933355
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