Dimethylformamide → HCID 13393784, Verbindung
Reaktionsgleichung
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=O)[CH2:5][CH:6]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[O:7]2.P(Cl)(Cl)([Cl:21])=O.CN(C)[CH:26]=[O:27]>>[Cl:21][C:4]1[C:3]2[C:8](=[CH:9][CH:10]=[CH:11][C:2]=2[OH:1])[O:7][CH:6]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:5]=1[CH:26]=[O:27]Komponenten
4
Versuchsvorschrift
As in example 1, but using 2.4 g 5-hydroxy-flavanone, 20 ml dimethylformamide and 2.8 ml phosphorous oxychloride. Reaction time is forty hours at 75° C. After hydrolysis and usual work up the residual solid is purified by column chromatography. The best fractions are recrystallised in a mixture of toluene and hexane to give pure yellow crystalline 4-chloro-3-formyl-5-hydroxy-flav-3-ene; m.p. 165° C.
Aufarbeitung
- customReaction time