4,4,4-Trifluoro-1-(4-trifluoromethylphenyl)-1,3-butanedione → HCID 86598660, Verbindung

HRID 2108425Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2108425
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[CH2:10][C:11](=O)[C:12]([F:15])([F:14])[F:13])=[CH:5][CH:4]=1.[NH2:20][C:21]1[C:25]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=2)=[CH:24][NH:23][N:22]=1>>[F:1][C:2]([F:19])([F:18])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]([C:12]([F:15])([F:14])[F:13])[N:22]3[N:23]=[CH:24][C:25]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][N:27]=4)=[C:21]3[N:20]=2)=[CH:5][CH:4]=1

Komponenten

3

Edukt 2

HCID 108590204,4,4-Trifluoro-1-(4-trifluoromethylphenyl)-1,3-butanedioneHCID 178509250HCID 178509250, Verbindung

Produkt 1

HCID 86598660HCID 86598660, VerbindungAusbeute 71 %

Versuchsvorschrift

Reaction of 1-(4-trifluoromethyl-phenyl)-4,4,4-trifluoro-butane-1,3-dione (142 mg, 0.5 mmol), prepared from commercially available 3,4-dichloro-acetophenone according to general procedure A, and 3-amino-4-(2-pyridinyl)-pyrazole [CAS No. 493038-87-2; prepared from 2-cyanomethyl-pyridine as described in Bioorg. Med. Chem. Lett. 12 (2002) 3537-3541] (80 mg, 0.5 mmol) according to general procedure B yielded the title compound as a yellow solid (145 mg, 71%). MS (ISP) 409.2 [(M+H)+]; mp 202° C.

Quellen und Nachweise

ORD-Eintrag
ord-c28b3e3230304149971c769bf0454425
Quelldatensatz
uspto-grants-2009_04
Patentnummer
US07514443B2

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