4-Bromophenol → HCID 23062453, Verbindung

HRID 2109374

Reaktionsgleichung

Reaktionsgleichung von HRID 2109374
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH3:9][C:10]1[C:17]([CH3:18])=[CH:16][C:15]([CH3:19])=[C:14]([CH3:20])[C:11]=1[CH2:12]Cl.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:20][C:14]1[C:15]([CH3:19])=[CH:16][C:17]([CH3:18])=[C:10]([CH3:9])[C:11]=1[CH2:12][O:8][C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=1

Komponenten

5

Edukt 3

HCID 78084-BromophenolHCID 11430Potassium CarbonateHCID 819393-(Chloromethyl)-1,2,4,5-tetramethylbenzene

Produkt 1

HCID 23062453HCID 23062453, VerbindungAusbeute 79 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

In acetone (50 ml), a mixture of 4-bromophenol (7.8 g), 2,3,5,6-tetramethylbenzyl chloride (6.3 g) and potassium carbonate (6.5 g) was heated at reflux for 16 hours. The reaction solution was filtered, and the filtrate was concentrated under reduced pressure. The residue was dissolved in ethyl acetate, and successively washed with 3% aqueous sodium hydroxide solution, water and saturated brine. The solvent was evaporated under reduced pressure, thereby giving 8.7 g of the desired compound.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 16 hours
  3. filtrationThe reaction solution was filtered
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. dissolutionThe residue was dissolved in ethyl acetate
  6. washsuccessively washed with 3% aqueous sodium hydroxide solution, water and saturated brine
  7. customThe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-52c09326b92d4d6db679987c70e3e86c
Quelldatensatz
uspto-grants-2009_04
Patentnummer
US07514452B2

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