AR-R-17779 → (R)-3'-(2-(4-Pyridyl)thiophen-4-yl)spiro[1-azabicyclo[2.2.2]octan-3,5'-oxazolidin]-2'-one

HRID 2109444Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2109444
[O:1]1[C@@:5]2([CH:10]3[CH2:11][CH2:12][N:7]([CH2:8][CH2:9]3)[CH2:6]2)[CH2:4][NH:3][C:2]1=[O:13].Br[C:15]1[CH:16]=[C:17]([C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)[S:18][CH:19]=1>[Cu]I>[N:23]1[CH:22]=[CH:21][C:20]([C:17]2[S:18][CH:19]=[C:15]([N:3]3[CH2:4][C@:5]4([CH:10]5[CH2:11][CH2:12][N:7]([CH2:8][CH2:9]5)[CH2:6]4)[O:1][C:2]3=[O:13])[CH:16]=2)=[CH:25][CH:24]=1

Komponenten

4

Edukt 2

HCID 5310971AR-R-17779HCID 576342694-(4-Bromothiophen-2-yl)pyridine

Produkt 1

HCID 11152019(R)-3'-(2-(4-Pyridyl)thiophen-4-yl)spiro[1-azabicyclo[2.2.2]octan-3,5'-oxazolidin]-2'-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)Katalysator

Versuchsvorschrift

The title compound was prepared by a method analogous to that described in Preparation 3 from (S)-spiro[1-azabicyclo[2.2.2]octan-3,5′-oxazolidin]-2′-one and 4-bromo-2-(4-pyridyl)thiophene using 2 equivalents of copper (I) iodide. The title compound (1.70 g) was obtained as a pale-yellow solid, m/z 342 (MH+).

Aufarbeitung

  1. customThe title compound was prepared by a method analogous to

Quellen und Nachweise

ORD-Eintrag
ord-a592b0ae6bdd4cd39f51893350ead82b
Quelldatensatz
uspto-grants-2009_04
Patentnummer
US07514567B2

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