Dimethyl Sulfate → 4-Methyl-4-[2-(2-nitrophenoxy)ethyl]morpholin-4-ium methylsulfate

HRID 2109961Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2109961
[N+:1]([C:4]1[CH:18]=[CH:17][CH:16]=[CH:15][C:5]=1[O:6][CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)([O-:3])=[O:2].[S:19]([O:24]C)([O:22][CH3:23])(=[O:21])=[O:20]>C(OCC)(=O)C>[CH3:23][O:22][S:19]([O-:24])(=[O:21])=[O:20].[CH3:23][N+:9]1([CH2:8][CH2:7][O:6][C:5]2[CH:15]=[CH:16][CH:17]=[CH:18][C:4]=2[N+:1]([O-:3])=[O:2])[CH2:10][CH2:11][O:12][CH2:13][CH2:14]1

Komponenten

4

Edukt 2

HCID 6497Dimethyl SulfateHCID 8673614-[2-(2-Nitrophenoxy)ethyl]morpholine

Produkt 1

HCID 867608464-Methyl-4-[2-(2-nitrophenoxy)ethyl]morpholin-4-ium methylsulfate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

2.52 g (10 mmol) of the product from Step 5.1 was dissolved in 30 mL of ethyl acetate, 1.4 g (11 mmol) of dimethyl sulfate was added and the mixture was allowed to agitate at room temperature which caused the formation of a precipitate. After 4 hours, the mixture was filtered, and the filter cake was washed with a small amount of ethyl acetate. Drying at 40° C. under vacuum gave 2.3 g (61% of the theoretical) of a beige-colored, slightly sticky product.

Aufarbeitung

  1. filtrationthe mixture was filtered
  2. washthe filter cake was washed with a small amount of ethyl acetate
  3. customDrying at 40° C. under vacuum
  4. customgave 2.3 g (61% of the theoretical) of a beige-colored, slightly sticky product

Quellen und Nachweise

ORD-Eintrag
ord-b60d1fd79db44723860aed2af5a8fa1e
Quelldatensatz
uspto-grants-2009_04
Patentnummer
US07517367B2

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