Sodium Hydroxide → 2-Amino-5-fluorobenzenesulfonamide

HRID 2110041Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2110041
[F:1][C:2]1[CH:14]=[CH:13][C:5]2[NH:6]C(=O)[NH:8][S:9](=[O:11])(=[O:10])[C:4]=2[CH:3]=1.[OH-].[Na+]>S(=O)(=O)(O)O>[NH2:6][C:5]1[CH:13]=[CH:14][C:2]([F:1])=[CH:3][C:4]=1[S:9]([NH2:8])(=[O:11])=[O:10]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 110960067-Fluoro-2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide

Produkt 1

HCID 224818252-Amino-5-fluorobenzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

After suspending 7-fluoro-2H,4H-benzo[e]1,2,4-thiadiazine-1,1,3-trione (3.00 g, 13.9 mmol) in 50% sulfuric acid (90 mL), the mixture was stirred at 130° C. for 1 hour. The reaction mixture was cooled in an ice bath while adding 40% aqueous sodium hydroxide for neutralization. The aqueous solution was concentrated under reduced pressure to 200 mL, and the precipitate was filtered out. It was then suspended in ethyl acetate (100 mL), and the insoluble portion was filtered out. The filtrate was concentrated under reduced pressure and dried to obtain 2-amino-5-fluorobenzenesulfonamide.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled in an ice bath
  2. concentrationThe aqueous solution was concentrated under reduced pressure to 200 mL
  3. filtrationthe precipitate was filtered out
  4. filtrationthe insoluble portion was filtered out
  5. concentrationThe filtrate was concentrated under reduced pressure
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-4c7688e9116d4f11b1cd46d0f5473ca6
Quelldatensatz
uspto-grants-2009_04
Patentnummer
US07517875B2

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