4-Methylphenyl isocyanate → HCID 23023097, Verbindung

HRID 2110082Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2110082
[C:1]1([CH3:10])[CH:6]=[CH:5][C:4]([N:7]=[C:8]=[O:9])=[CH:3][CH:2]=1.[CH3:11][O:12][C:13]1[CH:19]=[C:18]([O:20][CH3:21])[C:17]([C:22]([F:25])([F:24])[F:23])=[CH:16][C:14]=1[NH2:15]>CCOC(C)=O>[CH3:11][O:12][C:13]1[CH:19]=[C:18]([O:20][CH3:21])[C:17]([C:22]([F:24])([F:23])[F:25])=[CH:16][C:14]=1[NH:15][C:8]([NH:7][C:4]1[CH:5]=[CH:6][C:1]([CH3:10])=[CH:2][CH:3]=1)=[O:9]

Komponenten

4

Edukt 2

HCID 693254-Methylphenyl isocyanateHCID 27800032,4-dimethoxy-5-(trifluoromethyl)aniline

Produkt 1

HCID 23023097HCID 23023097, VerbindungAusbeute 89,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

p-Tolyl isocyanate (0.16 mL, 1.24 mmol) was added to a solution of 2,4-dimethoxy-5-(trifluoromethyl)aniline (0.25 g, 1.13 mmol) in EtOAc (3 mL) and the resulting mixture was stirred at room temp. for 18 h. The resulting precipitate was washed with Et2O to give the title compound as a white solid (0.36 g): 1H-NMR (CDCl3) δ 2.21 (s, 3H), 3.97 (s, 3H), 3.86 (s, 3H), 6.88 (s, 1H), 7.05 (d, J=8.5 Hz, 2H), 7.29 (d, J=8.5 Hz, 2H), 8.13 (s, 1H), 8.33 (s, 1H), 9.09 (s, 1H); FAB-MS m/z 355 ((M+1)+). B1e. General Method for the Reaction of an Aryl Amine with an Aryl Isocyanate

Aufarbeitung

  1. washThe resulting precipitate was washed with Et2O

Quellen und Nachweise

ORD-Eintrag
ord-5db46d012927401393f118a0eb664905
Quelldatensatz
uspto-grants-2009_04
Patentnummer
US07517880B2

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