2-Chloro-3-iodo-5-nitropyridine → 5-Amino-2-chloro-3-iodopyridine
Reaktionsgleichung
[Cl:1][C:2]1[C:7]([I:8])=[CH:6][C:5]([N+:9]([O-])=O)=[CH:4][N:3]=1>[Fe]>[NH2:9][C:5]1[CH:6]=[C:7]([I:8])[C:2]([Cl:1])=[N:3][CH:4]=1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
2-Chloro-3-iodo-5-nitropyridine (0.25 g, 0.88 mmol) was reacted with iron powder (0.25 g, 4.4 mmol) in the manner described in example 762D. Removal of the solvent in vacuo gave compound 765C (0.172 g, 77%). as a golden yellow solid. HPLC: 100% at 2.32 min(YMC S5 ODS column) eluting with 10-90% aqueous methanol containing 0.2% phosphoric acid over a 4 min gradient monitoring at 220 nm. MS (ES): m/z 255.03 [M+H]+.
Aufarbeitung
- customRemoval of the solvent in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-e5d2196bcf8d4072b8baf84c60c91652
- Quelldatensatz
- uspto-grants-2009_04
- Patentnummer
- US07517904B2
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