2-Methoxy-4-nitrobenzonitrile → 4-Amino-2-methoxybenzonitrile

HRID 2110503

Reaktionsgleichung

Reaktionsgleichung von HRID 2110503
[CH3:1][O:2][C:3]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[CH:7][C:4]=1[C:5]#[N:6]>[Fe].CC(O)=O.CCOC(C)=O>[NH2:11][C:9]1[CH:8]=[CH:7][C:4]([C:5]#[N:6])=[C:3]([O:2][CH3:1])[CH:10]=1

Komponenten

4

Edukt 1

HCID 2918672-Methoxy-4-nitrobenzonitrile

Produkt 1

HCID 2327354-Amino-2-methoxybenzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23925IronKatalysator2×HCID 22609514Ethyl acetate acetateLösungsmittel

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

2-Methoxy-4-nitro-benzonitrile (500 mg, 2.81 mmol) was suspended into 4 mL AcOH/EtOAc (1:1) and the resulting mixture was heated to 75° C. to give a clear solution. Fe powder (313 mg, 5.61 mmol, 325 Mesh) was added and the mixture was stirred for 30 min, after which additional Fe powder (313 mg, 5.61 mmol, 325 Mesh) was introduced. The mixture was stirred at 75° C. for an additional 30 min, and then cooled to rt and filtered, eluting with EtOAc. The filtrate was concentrated in vacuo, re-dissolved in EtOAc, filtered (eluting with EtOAc) and concentrated. Purification was achieved by silica gel flash chromatography with 0 to 10% MeOH in CH2Cl2 to give compound 848A as a tan solid.

Aufarbeitung

  1. customto give a clear solution
  2. stirringThe mixture was stirred at 75° C. for an additional 30 min
  3. temperaturecooled to rt
  4. filtrationfiltered
  5. washeluting with EtOAc
  6. concentrationThe filtrate was concentrated in vacuo
  7. dissolutionre-dissolved in EtOAc
  8. filtrationfiltered
  9. wash(eluting with EtOAc)
  10. concentrationconcentrated
  11. customPurification

Quellen und Nachweise

ORD-Eintrag
ord-df22aa894c0a47e88495e10cc4b34e6f
Quelldatensatz
uspto-grants-2009_04
Patentnummer
US07517904B2

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