HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → 3-Amino-6-(benzofuran-2-yl)phtalimide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | Tri-o-tolylphosphine | HCID 80271 | — |
| Edukt | Benzo[b]furan-2-boronic acid | HCID 2776266 | — |
| Edukt | 4-amino-7-bromo-2,3-dihydro-1H-isoindole-1,3-dione | HCID 68489089 | — |
| Katalysator | palladium(II) acetate | HCID 167845 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | 3-Amino-6-(benzofuran-2-yl)phtalimide | HCID 68492265 | 33% |
Reaktionsschritte
In a similar manner to Step 2 of Example 1, 3-amino-6-bromophthalimide (80.0 mg, 0.332 mmol) was dissolved in acetonitrile (4.0 mL), and, the solution was treated with 2-benzofuraneboronic acid (161 mg, 0.996 mmol), palladium acetate (9.0 mg, 0.040 mmol), tri(o-tolyl)phosphine (24.3 mg, 0.080 mmol) and triethylamine (0.463 mL, 3.32 mmol), followed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=15/1) to obtain Compound 171 (30.1 mg, yield 33%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07745641B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-a4efae9c91d74fb0a4807b3ad512d487 |
| Quellennotiz | uspto-grants-2010_06 |