Reaktionsgleichung
C[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[S:7])=[CH:4][CH:3]=1.[C:10](Cl)(=[O:12])[CH3:11]>>[C:10]([SH:7]=[CH:6][C:5]1[CH:4]=[CH:3][CH:2]=[CH:9][CH:8]=1)(=[O:12])[CH3:11]Komponenten
Versuchsvorschrift
Two other S-protected p-thiobenzaldehydes were obtained as shown in Scheme 2 (FIG. 15). The thiocyanato-benzaldehyde 8 was prepared according to a general procedure (Suzuki and Abe (1996) Synth. Commun., 26: 3413-3419) in 20% yield. All attempts to improve the yield by replacement of DMF with 1,3-dimethyl-2-imidazolidinone, increasing the temperature, or prolonging the reaction time were unsuccessful. S-Acetylthiobenzaldehyde 9 was prepared in a two-step one-flask procedure. Cleavage of the methyl group of 4-methylthiobenzaldehyde according to a general procedure (Tiecco et al. (1982) Synthesis, 478-480) followed by trapping of the resulting anion with acetyl chloride afforded the desired S-acetylthiobenzaldehyde 9 in 55% yield.
Aufarbeitung
- temperatureincreasing the temperature
- customS-Acetylthiobenzaldehyde 9 was prepared in a two-step one-flask procedure
Quellen und Nachweise
- ORD-Eintrag
- ord-faeb84eeefc64c9fb7da96270a2c87da
- Quelldatensatz
- uspto-grants-2009_04
- Patentnummer
- US07518905B2
Verknüpfte Notizen
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