4-Vinylbenzaldehyde → 4-Vinylbenzaldehyde

HRID 2111450

Reaktionsgleichung

Reaktionsgleichung von HRID 2111450
[C:1]([OH:4])(=S)[CH3:2].[CH:5]([C:7]1[CH:14]=[CH:13][C:10]([CH:11]=[O:12])=[CH:9][CH:8]=1)=[CH2:6]>CN(C=O)C>[CH:10]([C:9]1[CH:8]=[CH:7][CH:5]=[CH:6][C:2]=1[CH:1]=[O:4])=[CH2:11].[CH:5]([C:7]1[CH:14]=[CH:13][C:10]([CH:11]=[O:12])=[CH:9][CH:8]=1)=[CH2:6]

Komponenten

5

Edukt 2

HCID 393894-VinylbenzaldehydeHCID 178418634HCID 178418634, Verbindung

Produkt 2

HCID 393894-VinylbenzaldehydeHCID 39391Benzaldehyde, 2-ethenyl-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Aldehyde 11 was synthesized by radical addition (Lub et al. (1997) Liebigs Ann. Recueil, 2281-2288) of thioacetic acid to 4-vinylbenzaldehyde. Vinyl benzaldehyde was synthesized by the procedure of Ren et al. (1993) Bull. Chem. Soc. Jpn. 66: 1897-1902 with the following changes: The addition of DMF was performed at a 38 mmol scale at 0° C. Purification by column chromatography (silica, Et2O/hexanes, 1:3) afforded 4-vinylbenzaldehyde in 60% yield (FIG. 37)/

Aufarbeitung

  1. customwas performed at a 38 mmol scale at 0° C
  2. customPurification by column chromatography (silica, Et2O/hexanes, 1:3)

Quellen und Nachweise

ORD-Eintrag
ord-bf61f8e028394939abd8e955c70d1b94
Quelldatensatz
uspto-grants-2009_04
Patentnummer
US07518905B2

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