Mesitene lactone → 4,6-Dimethylisobenzofuran-1,3-dione

Reaktionsgleichung

[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])OC(=O)[CH:3]=1.Cl[C:11]1[C:12]([O:14][C:15](=[O:17])[CH:16]=1)=[O:13]>>[CH3:8][C:6]1[CH:7]=[C:2]([CH3:3])[CH:1]=[C:11]2[C:12]([O:14][C:15](=[O:17])[C:16]=12)=[O:13]

Komponenten

Edukt 2

HCID 12662Mesitene lactone

HCID 66772Chloromaleic anhydride

Produkt 1

HCID 145747334,6-Dimethylisobenzofuran-1,3-dioneAusbeute 63,8 %

Reaktionsbedingungen

Temperatur: 160 °C

Versuchsvorschrift

4,6-dimethyl-2-pyrone (1.0 g, 8.1 mmol) and 2-chloromaleic anhydride (1.5 g, 11 mmol) were stirred with heating at 160° C. for 3 hrs, and the precipitated crystals were purified by silica gel chromatography (chloroform) to give 0.91 g of the title compound.

Aufarbeitung

customthe precipitated crystals were purified by silica gel chromatography (chloroform)

Quellen und Nachweise

ORD-Eintrag: ord-d24c354f98eb4d30a596ec06a0799689
Quelldatensatz: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07521451B2

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