3-(Trifluoromethyl)phenyl isocyanate → HCID 135500083, Verbindung

HRID 2111965Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2111965
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[NH:13][C:12](=[O:14])[O:11][N:10]=1.[F:15][C:16]([F:27])([F:26])[C:17]1[CH:18]=[C:19]([N:23]=[C:24]=[O:25])[CH:20]=[CH:21][CH:22]=1>C1COCC1>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]2[NH:13][C:12](=[O:14])[O:11][N:10]=2)=[C:2]([NH:1][C:24]([NH:23][C:19]2[CH:20]=[CH:21][CH:22]=[C:17]([C:16]([F:15])([F:26])[F:27])[CH:18]=2)=[O:25])[CH:7]=1

Komponenten

4

Edukt 2

HCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 1360346823-(2-Amino-4-chlorophenyl)-1,2,4-oxadiazol-5(2H)-one

Produkt 1

HCID 135500083HCID 135500083, VerbindungAusbeute 63 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

3-(2-Amino-4-chloro-phenyl)-4H-[1,2,4]oxadiazol-5-one (400 mg, 1.92 mmol) was dissolved in 20 ml dry THF and 3-trifluoromethyl-phenyl-isocyanate (450 mg, 2.40 mmol) was added and the reaction stirred for 16 hours. The solvent was reduced under vacuum and the product recrystallised from ethyl acetate and heptane to yield 480 mg (63%) of off-white crystalline solid (m.p. 246-248; decomposition).

Aufarbeitung

  1. customthe product recrystallised from ethyl acetate and heptane

Quellen und Nachweise

ORD-Eintrag
ord-06d71198e0ec4e3da5527ee67b1bc718
Quelldatensatz
uspto-grants-2009_04
Patentnummer
US07521480B2

Notizen zur Reaktion

Wird geladen…