Triethylamine → HCID 86594426, Verbindung

A mixture of (S)-2-tert-butoxycarbonylamino-4-iodobutyric acid methyl ester (0.200 g, 0.58 mmol), (2-methoxyethyl)-methylamine (0.062 g, 0.70 mmol), and triethylamine (0.41 mL, 2.9 mmol) in dioxane (1 mL) was stirred at 70° C. for 16 hours. The mixture was cooled to room temperature, concentrated under reduced pressure, and dissolved in dichloromethane (20 mL). The solution was washed with water (3×10 mL), brine (10 mL), dried over MgSO4, filtered through Celite, and concentrated under reduced pressure. The tan oil was chromatographed eluting with ether to provide 0.87 g of pale yellow oil (49% yield).

1. temperatureThe mixture was cooled to room temperature
2. concentrationconcentrated under reduced pressure
3. dissolutiondissolved in dichloromethane (20 mL)
4. washThe solution was washed with water (3×10 mL), brine (10 mL)
5. dry with materialdried over MgSO4
6. filtrationfiltered through Celite
7. concentrationconcentrated under reduced pressure
8. customThe tan oil was chromatographed
9. washeluting with ether

ORD-Eintrag

ord-5b95a39dda4e4d7693709aea2ce7b1eb

Quelldatensatz

uspto-grants-2009_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07521447B2