Diisobutylaluminumhydride → HCID 178486508, Verbindung

Reaktionsgleichung

NC1C=C(OC)C(OC)=CC=1C(C1C=CC=CC=1Cl)=O.NC1C(C)=NN(CC=C)C=1Cl.[Cl:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[C:39]1[C:45]2[CH:46]=[C:47]([O:52][CH3:53])[C:48]([O:50][CH3:51])=[CH:49][C:44]=2[N:43]=[C:42]2[N:54](CC=C)[NH:55][C:56]([CH3:57])=[C:41]2[N:40]=1.[H-].C([Al+]CC(C)C)C(C)C>>[Cl:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[C:39]1[C:45]2[CH:46]=[C:47]([O:52][CH3:53])[C:48]([O:50][CH3:51])=[CH:49][C:44]=2[N:43]=[C:42]2[NH:54][NH:55][C:56]([CH3:57])=[C:41]2[N:40]=1

Komponenten

Edukt 4

HCID 21225700Diisobutylaluminumhydride

HCID 576423441-Allyl-5-chloro-3-methyl-1H-pyrazol-4-amine

HCID 57642368(2-Amino-4,5-dimethoxyphenyl)-(2-chlorophenyl)-methanone

HCID 178456649HCID 178456649, Verbindung

Produkt 1

HCID 178486508HCID 178486508, Verbindung

Versuchsvorschrift

5-(2-chlorophenyl)-1,2-dihydro-7,8-dimethoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine (IVx) was prepared by reacting 0.00093 moles of (2-amino-4,5-dimethoxyphenyl)(2-chlorophenyl)-methanone (Xx) with 4-amino-5-chloro-3-methyl-1-(2-propenyl)-1H-pyrazole (XIII), and subsequent dealkylation of the intermediate, 5-(2-chlorophenyl)-1,2-dihydro-7,8-dimethoxy-3-methyl-1-(2-propenyl)-pyrazolo[3,4-b][1,4]benzodiazepine (XIVx) with diisobutylaluminum hydride in a manner analogous to Example 72. MH+/Z=369.