Sodium Bicarbonate → 4-Acetamido-3-hydroxyphenyl acetate

HRID 2112740Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2112740
[C:1]([O:4][C:5]1[CH:14]=[CH:13][C:8]2[N:9]=[C:10]([CH3:12])[O:11][C:7]=2[CH:6]=1)(=[O:3])[CH3:2].FC(F)(F)C(O)=[O:18].O.C([O-])(O)=O.[Na+]>C1COCC1>[C:1]([O:4][C:5]1[CH:14]=[CH:13][C:8]([NH:9][C:10](=[O:18])[CH3:12])=[C:7]([OH:11])[CH:6]=1)(=[O:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 516892Sodium BicarbonateHCID 156622632-Methylbenzo[d]oxazol-6-yl acetateHCID 22392675Trifluoroacetic acid water

Produkt 1

HCID 688181524-Acetamido-3-hydroxyphenyl acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 2-methyl-1,3-benzoxazol-6-yl acetate (5.05 g, 28.8 mmol) in THF (100 mL) a mixture of trifluoroacetic acid/water (4 mL/10 mL) was added. The reaction mixture was stirred at room temperature for 16 hours, saturated aqueous NaHCO3 (150 mL) was added. The mixture was extracted with ethyl acetate, dried over Na2SO4, filtered and concentrated in vacuo to give sub-title compound (4.0 g) as a crude product.

Aufarbeitung

  1. additionwas added
  2. extractionThe mixture was extracted with ethyl acetate
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ad3ad19dac9d46f0ba6b56b1395b4f67
Quelldatensatz
uspto-grants-2009_04
Patentnummer
US07524856B2

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