[1,1'-Biphenyl]-4-carboxylicacid, 4'-bromo-, methyl ester → [4-(4-Bromophenyl)phenyl]methanol

Temperatur

0 °C

A solution of 4′-Bromo-biphenyl-4-carboxylic acid methyl ester, 7.8 g (27.9 mmol) in 150 mL of tetrahydrofuran was cooled to 0° C. via ice-water bath. Lithiumaluminum-hydride, 1.1 g (27.9 mmol) was added to the solution in one portion. The reaction mixture stirred at 0° C. for 1 h. The mixture was slowly quenched with 10 mL of isopropyl alcohol, then with 10 mL of water. The aqueous mixture was extracted with 3×50 mL portions of ethyl acetate. The organic layers were combined, washed with sat. aq. NaCl, and dried (MgSO4). The solution was concentrated to afford the desired product in 7.01 g (100%) as a white solid. The material was taken to the next step without further purification.

1. customThe mixture was slowly quenched with 10 mL of isopropyl alcohol
2. extractionThe aqueous mixture was extracted with 3×50 mL portions of ethyl acetate
3. washwashed with sat. aq. NaCl
4. dry with materialdried (MgSO4)
5. concentrationThe solution was concentrated

ORD-Eintrag

ord-4f3499ac49ef450c9fb89fc61b9f1bb4

Quelldatensatz

uspto-grants-2009_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07524878B2