Thionyl Chloride → 2-Chloro-4-(chloromethyl)-6-methylpyridine

HRID 2113634Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2113634
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8]O)[CH:5]=[C:4]([CH3:10])[N:3]=1.S(Cl)([Cl:13])=O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][Cl:13])[CH:5]=[C:4]([CH3:10])[N:3]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 22504306(2-Chloro-6-methylpyridin-4-yl)methanol

Produkt 1

HCID 216981672-Chloro-4-(chloromethyl)-6-methylpyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

2.2 1.14 g of (2-chloro-6-methylpyridin-4-yl)methanol are initially introduced in 50 ml of toluene, and 1.05 ml of thionyl chloride are slowly added dropwise with ice cooling. The mixture is boiled under reflux overnight. After cooling, the solvent is removed, giving 2-chloro-4-chloromethyl-6-methylpyridine as brown oil (1.1 g).

Aufarbeitung

  1. temperatureunder reflux overnight
  2. temperatureAfter cooling
  3. customthe solvent is removed

Quellen und Nachweise

ORD-Eintrag
ord-e624334278f045eebad3125f2b59d0fb
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07432282B2

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