Sodium Hydroxide → HCID 6483399, Verbindung

HRID 2113815Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2113815
[OH-].[Na+].C[O:4][C:5](=[O:17])[C:6]1[CH:11]=[C:10]([OH:12])[CH:9]=[C:8]([O:13][CH:14]([CH3:16])[CH3:15])[CH:7]=1>CO>[OH:12][C:10]1[CH:9]=[C:8]([O:13][CH:14]([CH3:16])[CH3:15])[CH:7]=[C:6]([CH:11]=1)[C:5]([OH:17])=[O:4]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 23072925Methyl 3-hydroxy-5-isopropoxybenzoate

Produkt 1

HCID 6483399HCID 6483399, VerbindungAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

After adding 10 ml of 4N aqueous sodium hydroxide solution to a solution of the 3.0 g (14.3 mmol) of 5-hydroxy-3-isopropoxybenzoic acid methyl ester obtained in Production Example 59 in methanol (50 ml), the mixture was stirred at room temperature for 12 hours. The reaction mixture was concentrated under reduced pressure, and then saturated aqueous ammonium chloride was added, extraction was performed with chloroform, and the organic layer was dried and then concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (chloroform:methanol=50:1) to obtain 2.44 g of 5-hydroxy-3-isopropoxybenzoic acid (yield: 87%) as a white solid.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionsaturated aqueous ammonium chloride was added
  3. extractionextraction
  4. customthe organic layer was dried
  5. concentrationconcentrated under reduced pressure
  6. customThe obtained residue was purified by silica gel chromatography (chloroform:methanol=50:1)

Quellen und Nachweise

ORD-Eintrag
ord-9483fb199cad47a2bbb1dbfa8de292cf
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07432287B2

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