4-Thiazolecarboxylic acid → N-(4'-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1'-biphenyl-3-yl)thiazole-4-carboxamide

HRID 2114129

Reaktionsgleichung

Reaktionsgleichung von HRID 2114129
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:21])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH2:17][CH:18]3[CH2:20][CH2:19]3)=[O:15])=[CH:10][CH:9]=2)[CH:7]=1.[S:22]1[CH:26]=[C:25]([C:27](O)=[O:28])[N:24]=[CH:23]1>>[CH:18]1([CH2:17][NH:16][C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]3[C:5]([CH3:21])=[CH:4][CH:3]=[C:2]([NH:1][C:27]([C:25]4[N:24]=[CH:23][S:22][CH:26]=4)=[O:28])[CH:7]=3)=[CH:9][CH:10]=2)=[O:15])[CH2:20][CH2:19]1

Komponenten

3

Edukt 2

HCID 3042714-Thiazolecarboxylic acidHCID 113004885'-amino-N-(cyclopropylmethyl)-2'-methyl-1,1'-biphenyl-4-carboxamide

Produkt 1

HCID 69204006N-(4'-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1'-biphenyl-3-yl)thiazole-4-carboxamide

Versuchsvorschrift

N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)thiazole-4-carboxamide was prepared from 5′-amino-N-(cyclopropylmethyl)-2′-methyl-1,1′-biphenyl-4- carboxamide and thiazole-4-carboxylic acid using method D. NMR; δH [2H6]—DMSO 10.35, (1H, s), 9.26,(1H, d), 8.62,(1H, t), 8.47,(1H, d), 7.92,(2H, d), 7.78-7.76,(2H, m), 7.44,(2H, d), 7.28,(1H, d), 3.16,(2H, t), 2.20,(3H, s), 1.04,(1H, m), 0.44,(2H, m), 0.24,(2H, m). LCMS: retention time 3.25 min, MH+392.

Quellen und Nachweise

ORD-Eintrag
ord-571bc8fd543c4aa0b17fbee8c7f9b1b7
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07432289B2

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