Sodium Hydroxide → 3-(2,2'-Bisethylcarbamoyl-2-phenylethoxy)propionic acid

HRID 2114184Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2114184
C[O:2][C:3](=[O:25])[CH2:4][CH2:5][O:6][CH2:7][C:8]([C:20](=[O:24])[NH:21][CH2:22][CH3:23])([C:15](=[O:19])[NH:16][CH2:17][CH3:18])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[OH-].[Na+]>C1COCC1.CO>[CH2:17]([NH:16][C:15]([C:8]([C:20](=[O:24])[NH:21][CH2:22][CH3:23])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:7][O:6][CH2:5][CH2:4][C:3]([OH:25])=[O:2])=[O:19])[CH3:18]

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 587063943-(2,2'-Bisethylcarbamoyl-2-phenylethoxy)propionic acid methyl ester

Produkt 1

HCID 587063833-(2,2'-Bisethylcarbamoyl-2-phenylethoxy)propionic acidAusbeute 95,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

3-(2,2′-Bisethylcarbamoyl-2-phenylethoxy)propionic acid methyl ester (125 mg) was dissolved in THF (0.5 mL) and MeOH (0.5 mL), and 1N sodium hydroxide (0.5 mL) was added thereto. The solution was stirred at room temperature for 1 hour and then concentrated. The residue was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The extract was washed with water and concentrated to give 3-(2,2′-bisethylcarbamoyl-2-phenylethoxy)propionic acid (115 mg).

Aufarbeitung

  1. concentrationconcentrated
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with water
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-3ca82c3ad52940c8bf431d4ebb6d5cac
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07432392B2

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