Pyrazole → (r)-4-Bromo-5-(2-chlorobenzoylamino)-1-methyl-pyrazole-3-carboxylic acid (1,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1h-benzo[b][1,4]diazepin-3-yl)amide

HRID 2114308Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2114308
N1C=C[CH:3]=N1.[CH3:6][N:7]([C@@H:26]([C:28]1C=CC=C[CH:29]=1)C)[C:8](C1C(Br)=C(NC(=O)C2C=CC=CC=2Cl)NN=1)=[O:9].[Cl:34][C:35]1[CH:43]=[CH:42][CH:41]=[CH:40][C:36]=1[C:37](Cl)=[O:38].[N:44]1([CH2:49][CH2:50][NH:51][C:52]([C:54]2[C:58]([Br:59])=[C:57]([NH:60]C(=O)C3C=CC=CC=3Cl)[NH:56][N:55]=2)=[O:53])[CH2:48][CH2:47][CH2:46][CH2:45]1>>[CH3:6][N:7]1[C:8](=[O:9])[C@H:50]([NH:51][C:52]([C:54]2[C:58]([Br:59])=[C:57]([NH:60][C:37](=[O:38])[C:36]3[CH:40]=[CH:41][CH:42]=[CH:43][C:35]=3[Cl:34])[N:56]([CH3:3])[N:55]=2)=[O:53])[CH2:49][N:44]([CH3:45])[C:48]2[CH:47]=[CH:46][CH:29]=[CH:28][C:26]1=2

Komponenten

5

Edukt 4

HCID 1048PyrazoleHCID 691102-Chlorobenzoyl chlorideHCID 178461679HCID 178461679, VerbindungHCID 178522629HCID 178522629, Verbindung

Produkt 1

HCID 59773391(r)-4-Bromo-5-(2-chlorobenzoylamino)-1-methyl-pyrazole-3-carboxylic acid (1,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1h-benzo[b][1,4]diazepin-3-yl)amide

Versuchsvorschrift

The pyrazole acid, prepared by coupling methyl ester 85 (Gen. Proc. 26) with 2-chlorobenzoyl chloride (21) followed by hydrolysis and bromination as shown in Gen. Proc. 8. was coupled to compound 92 (Procedure 27) using the method of Procedure 3.

Aufarbeitung

  1. customfollowed by hydrolysis and bromination

Quellen und Nachweise

ORD-Eintrag
ord-f916f3bd86ef43c9848028e3ab5e0dd9
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07432379B2

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