Selectfluor → Methyl 5-fluoro-6-hydroxynaphthalene-1-carboxylate

HRID 2115855Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2115855
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([C:12]([O:14][CH3:15])=[O:13])=[CH:7][CH:6]=[CH:5]2.[B-](F)(F)(F)[F:17].[B-](F)(F)(F)F.C1[N+]2(CCl)CC[N+](F)(CC2)C1>C(#N)C.C(OCC)(=O)C>[F:17][C:3]1[C:2]([OH:1])=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]([O:14][CH3:15])=[O:13]

Komponenten

5

Edukt 2

HCID 2724933SelectfluorHCID 11367671Methyl 6-hydroxy-1-naphthoate

Produkt 1

HCID 24823729Methyl 5-fluoro-6-hydroxynaphthalene-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6342AcetonitrileLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

To a stirred solution of methyl 6-hydroxy-1-naphthoate (25 g, 123.8 mmol) in anhydrous acetonitrile (130 mL), SelectFluor (45 g, 127.5 mmol) was added and the reaction vessel sealed (sealed tube). The reaction mixture was heated to 85° C. for 3 d. The reaction mixture was allowed to cool to RT, diluted with ethyl acetate and washed with water, then brine, dried with Na2SO4, filtered and evaporated. The mixture was purified by column chromatography using methylene chloride as the eluent. The title compound was obtained as a tan solid.

Aufarbeitung

  1. customthe reaction vessel sealed
  2. custom(sealed tube)
  3. temperatureto cool to RT
  4. washwashed with water
  5. dry with materialbrine, dried with Na2SO4
  6. filtrationfiltered
  7. customevaporated
  8. customThe mixture was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-608bfee589bf4b24a5b5f17d04d56e73
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07435823B2

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