Cesium carbonate → HCID 24822778, Verbindung

HRID 2115857Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2115857
[F:1][C:2]1[C:11]([OH:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[C:7]2[C:13]([OH:15])=[O:14].C([O-])([O-])=O.[Cs+].[Cs+].Cl[C:23]1[C:32]2[C:27](=[CH:28][C:29]([O:35][CH3:36])=[C:30]([O:33][CH3:34])[CH:31]=2)[N:26]=[CH:25][CH:24]=1>CS(C)=O>[CH3:34][O:33][C:30]1[CH:31]=[C:32]2[C:27](=[CH:28][C:29]=1[O:35][CH3:36])[N:26]=[CH:25][CH:24]=[C:23]2[O:12][C:11]1[C:2]([F:1])=[C:3]2[C:8](=[CH:9][CH:10]=1)[C:7]([C:13]([OH:15])=[O:14])=[CH:6][CH:5]=[CH:4]2

Komponenten

5

Edukt 3

HCID 10796Cesium carbonateHCID 4596104-Chloro-6,7-dimethoxyquinolineHCID 248246045-Fluoro-6-hydroxynaphthalene-1-carboxylic acid

Produkt 1

HCID 24822778HCID 24822778, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

To a solution of 5-fluoro-6-hydroxy-1-naphthoic acid (1 g, 4.87 mmol) in DMSO (5 mL), Cs2CO3 (4.75 g, 14.61 mmol) was added in one portion. The mixture was stirred at RT 10 min. To the suspension, 4-chloro-6,7-dimethoxyquinoline (1.09 g, 4.87 mmol) was added and the mixture heated to 140° C. O/N. The mixture was allowed to cool to RT, pH adjusted to 7 and the resulting solid filtered and rinsed with water. The title compound was obtained as a tan solid.

Aufarbeitung

  1. temperaturethe mixture heated to 140° C
  2. temperatureto cool to RT
  3. filtrationthe resulting solid filtered
  4. washrinsed with water

Quellen und Nachweise

ORD-Eintrag
ord-576ded0f6cc246ffa3380d3cfc46126f
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07435823B2

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