Methylamine → HCID 68966054, Verbindung

Reaktionsgleichung

CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[CH:20]=[C:21]([F:22])[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:30][NH2:31]>>[F:22][C:21]1[C:15]2[O:14][CH:13]([CH2:12][NH:31][CH3:30])[CH2:17][C:16]=2[CH:18]=[C:19]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[CH3:29])[CH:20]=1

Komponenten

Edukt 2

HCID 6329Methylamine

HCID 86599281HCID 86599281, Verbindung

Produkt 1

HCID 68966054HCID 68966054, Verbindung

Versuchsvorschrift

The title compound was prepared (0.075 g, 75%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[7-fluoro-5-(2-methylphenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.141 g, 0.32 mmol) and methylamine (0.20 g, 6.4 mmol). mp 212-217° C. (dec).

Quellen und Nachweise

ORD-Eintrag: ord-486d128e46ef4baab0cd3358a7d6e709
Quelldatensatz: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07435837B2

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