Hydrochloric Acid → (4-Methoxycarbonylphenyl)-(3-hydroxypyridin-4-yl)-methanol hydrochloride

HRID 2116489Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2116489
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[O:19]COC)[OH:12])=[CH:7][CH:6]=1)=[O:4].[ClH:23]>CO>[ClH:23].[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]([CH:11]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[OH:19])[OH:12])=[CH:9][CH:10]=1)=[O:4]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 69220240(4-Methoxycarbonylphenyl)-[3-(methoxymethoxy)pyridin-4-yl]-methanol

Produkt 1

HCID 23103650(4-Methoxycarbonylphenyl)-(3-hydroxypyridin-4-yl)-methanol hydrochlorideAusbeute 81 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Next, a mixture of (4-methoxycarbonylphenyl)-[3-(methoxymethoxy)pyridin-4-yl]-methanol (2.06 g, 6.79 mmol), methanol (35 mL) and concentrated hydrochloric acid (4.4 mL) was heated under reflux for 20 minutes. After cooling to room temperature, the reaction mixture was concentrated. Methanol and ethyl acetate were added to the residue and the resulting precipitate was filtered to give (4-methoxycarbonylphenyl)-(3-hydroxypyridin-4-yl)-methanol hydrochloride (1.87 g, 81%).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 20 minutes
  3. concentrationthe reaction mixture was concentrated
  4. additionMethanol and ethyl acetate were added to the residue
  5. filtrationthe resulting precipitate was filtered

Quellen und Nachweise

ORD-Eintrag
ord-7ac00c7dfd4f4115be1636b672730a99
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07439232B2

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