Ngx-267 → (R)-2-Ethyl-8-methyl-1-thia-4,8-diaza-spiro[4.5]decan-3-one

HRID 2116583Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2116583
[CH2:1]([C@H:3]1[C:7](=[O:8])[NH:6][C:5]2([CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[S:4]1)[CH3:2]>C1CCCCC1>[CH2:1]([C@@H:3]1[C:7](=[O:8])[NH:6][C:5]2([CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[S:4]1)[CH3:2]

Komponenten

3

Edukt 1

HCID 10013505Ngx-267

Produkt 1

HCID 11694209(R)-2-Ethyl-8-methyl-1-thia-4,8-diaza-spiro[4.5]decan-3-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8078CyclohexaneLösungsmittel

Versuchsvorschrift

The obtained (R)-2-mercaptobutyric acid was purified by distillation and then reacted with ammonium acetate and 1-methyl-4-piperidone in boiling cyclohexane. The crude reaction mixture was analyzed by GC on a chiral column and found to contain AF267A accompanied by a small (2-3%) amount of AF267B.

Aufarbeitung

  1. distillationThe obtained (R)-2-mercaptobutyric acid was purified by distillation
  2. customreacted with ammonium acetate and 1-methyl-4-piperidone
  3. customThe crude reaction mixture

Quellen und Nachweise

ORD-Eintrag
ord-5d9a2257d1374c33bfcfb25fc22d07d0
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07439251B2

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