Methylamine → 2-(Methylamino)-2-oxoethyl 4-[(4-bromophenyl)oxy]-1-piperidinecarboxylate

HRID 2116600Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2116600
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][CH2:18][C:19]([O:21]CC)=O)=[O:16])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[CH3:24][NH2:25]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][CH2:18][C:19]([NH:25][CH3:24])=[O:21])=[O:16])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 6329MethylamineHCID 674168332-(Ethyloxy)-2-oxoethyl 4-[(4-bromophenyl)oxy]-1-piperidinecarboxylate

Produkt 1

HCID 674158442-(Methylamino)-2-oxoethyl 4-[(4-bromophenyl)oxy]-1-piperidinecarboxylate

Versuchsvorschrift

2.9 g (7.5 mmol) of 2-(ethyloxy)-2-oxoethyl 4-[(4-bromophenyl)oxy]-1-piperidinecarboxylate, prepared in Step 4.3., in solution in 10 ml of a 33% ethanolic solution of methylamine are stirred at ambient temperature for 20 hours. Following evaporation, the product is purified by chromatography on silica gel, eluting with ethyl acetate, to give 0.8 g of product in gum form, which is used as it is in the following step.

Aufarbeitung

  1. customevaporation
  2. customthe product is purified by chromatography on silica gel
  3. washeluting with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-fab878cb16f74ac1a4f79a9c129d2b4b
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07439257B2

Notizen zur Reaktion

Wird geladen…